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Toposelective synthesis under thermodynamic control and bioactivities of topoisomers based on diethoxycarbonyl glycoluri
Six topoisomers consisting of diethoxycarbonyl glycoluril have been successfully synthesized in one-pot by using a "figure-of-seven" building block through anti-connectivity and syn-connectivity reactions, respectively. The structures of all six topoisomers were first determined by X-ray crystallography. The finding that (±) CT isomers are the dominant products under thermodynamic control can be explained by the calculated relative energies of the six topoisomers. That the (±) CT isomers have the lowest energy is most likely due to the additional intramolecular electrostatic interactions between -NO2 and -OMe groups. The biological activities of the topoisomers were primitively investigated and the results of bioassay showed that the six topoisomers possessed obvious difference of herbicidal activity.
作 者: ZHOU Baohan YIN Guodong WANG Zhiguo CHEN Yunfeng WU Anxin WAN Jian 作者單位: Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Department of Chemistry, Central China Normal University, Wuhan 430079, China 刊 名: 科學(xué)通報(bào)(英文版) SCI 英文刊名: CHINESE SCIENCE BULLETIN 年,卷(期): 2006 51(17) 分類號: O4 關(guān)鍵詞: biological activity thermodynamic control topoisomer toposelective synthesis【Toposelective synthesis under thermo】相關(guān)文章:
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